BRD4 Bromodomain 1 Inhibitor Screening using a Homogeneous Proximity Assay

The study described in this application note demonstrates the combination of a homogeneous, time-resolved fluorescence resonance energy transfer (TR-FRET) assay with automated instrumentation and a high-throughput screening (HTS) multi-mode microplate reader that monitors BRD4 bromodomain 1 activity.