Bypassing LC system passivation requirements using ACQUITY PREMIER with MaxPeak HPS Technology

Chemical passivation is a common technique used to enhance chromatographic performance in sensitive applications. Without passivation, analytes that are particularly susceptible to surface adsorption have been shown to suffer from peak tailing and poor recovery or reproducibility when using conventional LC systems and columns. In this application note by Waters, an LC dedicated to protein and peptide analysis could only recover a phosphorylated peptide after system passivation. Find out how Waters ACQUITY PREMIER with MaxPeak HPS technology can provide an off the shelf solution, bypassing the need for system passivation as required by conventional LC technology.