CETSA for navigating the chemistry and exploring the biology of protein degraders

In this scientific poster, Pelago Bioscience showcases CETSA^®, a patented label-free technology designed to evaluate protein-ligand interactions within the native cellular environment of both the protein of interest (POI) and the E3 ligase. The CETSA^® Navigate HT platform allows for robust and sensitive confirmation of target engagement (TE), and it can simultaneously monitor PROTAC-mediated POI degradation using the same detection format. Additionally, the poster highlights the capability of the unbiased proteome-wide format, CETSA^® Explore, to provide further insights into the mechanism of action of degraders.