Characterization of PLGA Using SEC-MALS-VIS

In this application note, two commercially available samples were analyzed by SEC coupled to a Multi-Angle Light Scattering (MALS) detector (HELEOS), a refractive index detector (Optilab rEX), and a viscosity (VIS) detector (ViscoStar). The results demonstrate that SEC-MALS-VIS is an excellent method for the characterization of PLGA polyesters as it has the ability to determine not only the molar mass distribution, but to reveal subtle differences in PLGA’s molecular structure.