Characterization of polymer degradation with SEC-MALS

Examine the power of size-exclusion chromatography coupled with multi-angle light scattering (SEC-MALS) for polymer characterization, using polydioxanone (PDO) surgical sutures as a case study. SEC-MALS provides precise measurements of molar mass, size, and distribution without relying on calibration standards. The study highlights key metrics for analyzing polymer degradation, showcasing SEC-MALS as an essential tool for assessing polymer stability and performance in medical applications.