Chiral analysis of ibuprofen using a circular dichroism detector

Only the S enantiomer of ibuprofen has active antipyretic properties, but within the human body an enzymatic reaction can readily convert the R enantiomer into the S enantiomer. In this application note, JASCO demonstrates how a circular dichroism detector can help differentiate between two enantiomers, and distinguish between achiral impurities and enantiomers of interest.