Comparison of Single Use Bioreactor BIOSTAT® CultiBag RM and Reusable STR for Cultivation of CHO Cells in Serum Free Media

In this application note, Sartorius present a study of the cultivation of suspension adapted CHO-S and CHO-K1 cells in the single use bioreactor BIOSTAT® CultiBag RM compared to the BIOSTAT® B-DCU® with stirred glass vessels. Serum free chemically defined media was used for the propagation of cells. Growth characteristics and basic metabolic profiles were investigated.