Comparison of the effects of pharmaceutical compounds on tumor cells in 2D and 3D in vitro models using label-free, quantitative 4 dimensional holographic imaging

Development of in vitro models for the evaluation of drugs represents a useful approach as in vivo studies may be costly and time consuming. Ideal models should take into account the effects of the cellular microenvironment, which includes the extra-cellular matrix, stroma and neighboring cells. In this poster, the HoloMonitor^® M4 from Phase Holographic Imaging was used for label-free long-term kinetic cellular analysis, in order to compare the effects of pharmaceutical compounds on tumor cells.