Comparison of Two Cell Model Systems, Primary Human Hepatocytes and hiPSC-derived Hepatocytes to Determine the Hepatoxicity of Three Candidate Drugs Developed for Rheumatoid Arthritis

Using human induced pluripotent stem cell (hiPSC)-derived hepatocytes is an important new tool which offers unlimited supply of euploid cells from single donors. This study tests the hepatoxicity of three internal candidate drugs developed for the treatment of rheumatoid arthritis.