Control of Mixing and Temperature using a Mesoscale Flow Reactor

Electrophilic bromination is a useful reaction in synthesis. However, when molecular bromine is used as the electrophile (under adventitious acidic conditions) it can be difficult to control both the exothermic addition and to prevent subsequent bis-bromination of the desired mono-brominated product. In this application poster, a series of flow-through conditions were investigated using the automated FlowSyn Multi-Experiment Package to quickly profile the bromination reaction.