Corning® Ultra-Low Attachment Surface Plates Allow for Lentivirus Transduction of Human Osteoclast Precursor Cells

One step toward developing a novel gene therapy for treating bone metastases, is the engineering of osteoclast precursor cells (OcP) to serve as a cellular gene delivery system capable of killing cancer cells. This study evaluates transduction of OcP using a simple, pre-isolation enrichment and maintenance of the cells as a non-adherent culture utilizing a specific hydrophilic and nonionic cell surface.