Depicting the cellular architecture of the tumor microenvironment by integrating hyperplex immunofluorescence and automated image analysis

The tumor microenvironment (TME) is emerging as an important factor that shapes the dynamic of tumor growth, heterogeneity, and response to therapies. In this application eBook, Indica Labs focuses on the phenotyping of cells across different tumor types on a tissue microarray (TMA) with an immuno-oncology panel encompassing 20 biomarkers. They interrogated their TME with the use of the COMET™ automated staining and imaging system, and HALO^® and HALO AI image analysis platforms.