Depletion of host DNA significantly improved microbial analysis

In this product brochure, Molzym introduces MolYsis^™, which tackles the issue of limited microbial DNA presence in complex human or animal samples compared to host DNA. MolYsis employs a proprietary technology to selectively lyse host cells, leading to up to 99% reduction in host DNA. A subsequent lysis step targets intact bacteria and fungi cells, resulting in purified microbial DNA. This process can be conducted manually or automated using the SelectNA^™ plus device. The enhanced microbe-to-host DNA ratio achieved through this method significantly enhances sensitivity in subsequent NGS, PCR, and other molecular microbiological techniques.