Design and Implementation of a Simple Achiral Method Development Strategy for UPC² Chemistries

Method development strategies in SFC often take a brute force screening approach utilizing extensive libraries of column chemistries with multiple combinations of modifiers and additives. This poster presents a simplified method development strategy due to the introduction of novel ACQUITY UPC²™ Torus™ 2-PIC, DIOL, DEA, and 1-AA column chemistries. Instead of using a multi-column / co-solvent initial screening, the simplified strategy implements a rapid scouting step using Torus 2-PIC with methanol co-solvent and generic gradient.