Detection and Modulation of Cardiomyocyte Calcium Oscillations Using the FDSS6000

Current methodology to detect calcium oscillations in mouse fetal cardiomyocytes uses fluorescence microscopy to image cells plated on cover slips or Petri dishes. Cells are exposed to putative cardiomodulators to investigate their pharmacological or toxicological properties. This application note reports a methodology to transfer this model to high throughput screening using the FDSS6000.