ResourceSpectroscopy
Detection and Quantification of Formaldehyde by Derivatization with Pentafluorobenzylhydroxyl Amine in Pharmaceutical Excipients
12 Jul 2012This application note presents a simple and effective method for the determination of formaldehyde in pharmaceutical excipients using SHS-GC/MS. This is a fast and reliable method that can be used for the quantification of low-molecular-weight aldehydes in most excipients commonly used in pharmaceutical products. Excellent quantification and linear instrument response was reported across a 1 to 50 ppb concentration range of formaldehyde.