Detection of K-ras Point Mutations in the Pancreas by Constant Denaturing Gel Electrophoresis using the DCode™ System

Mutations of K-ras were thought to be quite rare in pancreases free of ductal adenocarcinoma. In this application note constant denaturing gel electrophoresis detected mutations in 16 samples from normal pancreases. This finding raises the question of which role K-ras mutations play in the series of genetic alterations leading to ductal adenocarcinoma of the pancreas.