Determination of Residual Solvents in Pharmaceutical Products Using Static Headspace and Time of Flight GC/MS

The USP 467 method is widely used for the identification and quantification of residual solvents in pharmaceutical products. In particular the USP 467 describes the use of static headspace sampler coupled with a GC-FID system in order to recognize and quantify organic volatile impurities. This poster shows the benefits obtained using the Headspace technique coupled with a GC/TOF-MS system capable of analyzing all classes of compounds in a single analysis drastically reducing the time analysis.