Determination of the presence of the number of modifications using a linear benchtop MALDI-TOF MS

Explore the analysis of antibody-drug conjugates (ADCs), combining antibody selectivity with small-molecule drugs for targeted cancer therapy. Using its MALDI 8020 Benchtop Linear MALDI-TOF Mass Spectrometer, Shimadzu demonstrates how to determine binding sites and characteristics of pseudo ADCs, created by binding low-molecular compounds to research antibodies. This method supports quality assessment and development of ADCs in pharmaceutical research.