Determination of Voriconazole Related Compound F in Voriconazole Using IC

This application note demonstrates a sensitive, repeatable, and accurate method using the solvent-compatible anion-exchange column specified in the proposed U.S. Pharmacopeia monograph for determining voriconazole related compound F in voriconazole. Determination can be made in 5 mg/mL sample solutions containing as low as 0.002% voriconazole related compound F.