Determining Residue on Ignition in Pharmaceutical and Nutraceutical Products by Gravimetric Loss on Ignition Analysis

Pharmaceutical and Nutraceutical companies have a responsibility to ensure the drugs they are distributing are not only safe and effective for the consumers but are consistent between different batches and manufactures; this involves measuring the residue on ignition (ROI). The % ROI describes the amount of total concentration of inorganic salts and trace metals that fail to ignite at 600 °C. In this application note, Arizona Instrument was able to demonstrate equivalency between the traditional muffle furnace method and the Computrac® MAX® 5000XL Moisture and Ash Analyzer for several vitamins and supplements.