Development of Low Extractable Syringe Filters for Liquid Chromatography/Mass Spectrometry Applications

This poster describes the development of the Acrodisc MS syringe filters. The cleanliness of filter effluents using Acrodisc MS syringe filters and two commercially available alternative syringe filters are compared by evaluating the presence of extractable/leachable compounds in the filter effluents under the same filtration and LC/ESI/MS analytical test conditions. Additionally, the ME (ion suppression/enhancement) due to potentially interfering extractable/leachable compounds is studied for the analyses of three drug substances by comparing the MS signal intensity of each drug substance spiked into the filter effluent against a control solution using fast gradient LC/ESI/MS.