Diastereoselective Separation of Permethrin Using the ACQUITY UPC2 System

Chirality plays an important role in the potency, toxicity, metabolic, and environmental fate of chiral pesticides. As a result, there has been an increasing demand for stereo-selective separation techniques and analytical assays to evaluate the enantiomeric purity of pesticides. This application note demonstrates a method for rapid baseline resolution of four isomers of permethrin, a synthetic chemical widely used as an insecticide and an insect repellent, using the ACQUITY UPC² system.