Differential recovery of gabapentin and pregabalin utilizing SPE extraction demonstrated in a 43-analyte urine confirmatory LC‑MS/MS panel

This poster describes an SPE extraction method followed by LC-MS/MS analysis for the complete recovery of gabapentin and pregabalin from urine while not impacting the complete recovery of most other analytes. This differential recovery can reduce the complications associated with samples with high concentration gabapentin and pregabalin, such as off-scale chromatography, carryover, and ion suppression.