Direct Injection of Polar Compounds in Highly Organic Protein Precipitated Plasma Using UPC2/MS/MS

By changing MS inlet technology from RPLC to UPC2, it is possible to directly inject polar compounds from highly organic samples for separation without additional sample preparation steps such as evaporation and reconstitution. This Technology brief illustrates UPC2 in a bioanalytical laboratory, providing a simplified methodology for the analysis of polar compounds in highly organic sample preparations.