Effect of Filtration Using Pall Acrodisc® MS Syringe Filters on the Lifespan of Ultra High Performance Liquid Chromatography Columns

This application note assesses the protective properties of the 0.2 μm rated Acrodisc MS syringe filter from Pall Life Sciences relative to 0.45 μm rated filters. The lifespan of the UHPLC column was deduced by monitoring column backpressure. The results demonstrate that the of Pall’s 0.2 μm Acrodisc MS syringe filter affords significant protection from clogging and extends the lifespan of the UHPLC column at least 50-fold.