Effortless and streamlined workflow for absolute quantitation of therapeutic monoclonal antibodies using Promise Proteomics mAbXmise kits and TSQ Altis Plus Mass Spectrometer

In this application note, Thermo Fisher Scientific discusses how laboratories continually strive for improved productivity and efficacy in clinical testing, aiming to impact turnaround time and sample throughput. Efforts to enhance efficiency include rapid and high-throughput testing, automation, and the use of high-end instrumentation. The focus is on mass spectrometry (MS), which has gained significant popularity in clinical laboratories for therapeutic drug monitoring (TDM) of monoclonal antibodies (mAbs) due to its versatility in qualitatively and quantitatively measuring complex biological proteins. The note outlines a streamlined workflow for the absolute quantitation of therapeutic mAbs, utilizing the Promise Proteomics mAbXmise kits and the Thermo Scientific™ TSQ Altis™ Plus mass spectrometer.