Emerging alternative analytical techniques for oligonucleotide separation and purification

As the therapeutic oligonucleotide market continues to mature, the need for alternative analytical approaches emerge to meet those demands. The current standard widely used for oligonucleotide analysis is ion-pairing reversed-phase chromatography (IP-RP) and ion-exchange chromatography (IEX). However, these instruments come with limitations such as, incompatibility and flexibility.

Explore an effective and emerging technique for oligonucleotide workflows – hydrophilic interaction chromatography (HILIC) and size exclusion chromatography (SEC) – and uncover the benefits it can provide for your separation and purification of oligonucleotides.