Emulation of a Waters Alliance LC for the analysis of metoclopramide and its impurities

Instrument-to-instrument method transfer is a crucial topic for many different industries, particularly for the regulated pharmaceutical industry. Agilent Intelligent System Emulation Technology (ISET) facilitates the seamless transfer of analytical methods from conventional LC systems to an Agilent UHPLC system. This Application Note demonstrates the straightforward transfer of an analytical method from the Waters Alliance 2695 LC to a 1260 Infinity II Prime LC by using ISET. Metoclopramide and its impurities were analyzed on both systems. Retention times and resolution of the different experiments were evaluated and compared.