Enantioselective Separation of Basic Compounds in SFC Mode

The enantioselective separation of chiral basic substances is of high interest especially in the pharmaceutical sector, as many pharmaceuticals are chiral bases. Often, one enantiomer shows higher pharmacological activity. The other one may be inactive or even toxic. More and more chiral separations are being performed in SFC mode, but there still remain some challenges for basic compounds. This application note describes the use of CHIRAL ART Amylose-SA for the determination and separation of 27 biologically active basic compounds.