Engineered E. coli with an oxidative cytoplasm and efficient cleavage of N-terminal methionine

Lees et al., have developed a novel E. coli expression system, named Gor/Met E. coli, with an oxidative intracellular environment that can express disulfide-bonded proteins as soluble, properly folded intracellular proteins. Download this poster for insight into the potential of the Gor/Met E. coli as a commercially viable production strain for producing high yields of disulfide-bonded proteins with their native sequence.