Evaluating HILIC stationary phases for oligonucleotide separation by LC/MS

Hydrophilic interaction chromatography (HILIC) represents a versatile and effective alternative to ion-pairing reversed-phase liquid chromatography (IP-RPLC) for analyzing oligonucleotides.

Find out more about a study where five different HILIC stationary phases were comprehensively evaluated and optimized to determine their suitability and complementarity for oligonucleotide analysis using liquid chromatography/mass spectrometry (LC/MS).