Extractables in single-use systems used in ADC manufacturing

Antibody-drug conjugates (ADCs) are biotherapeutic molecules consisting of a cytotoxin coupled to a monoclonal antibody (mAb) by a linker. Single-use (SU) systems are well suited to ADC manufacturing for several reasons, such as minimizing operator exposure to toxins. Cytiva supports the adoption of SU technologies in ADC production by extractables studies, with conditions relevant to current ADC manufacturing processes. Discover how three SU products: ReadyToProcess™ 1 L column housing, disposable ÄKTA ready™ low flow kit for chromatographic systems, and ÄKTA readyflux™ flow kit for tangential flow filtration, demonstrate low levels of extractables with organic solvents DMSO and DMA.