Extraction of Cocaine and Metabolites from Biological Fluids using EVOLUTE CX

Read this application note to learn a procedure recommended for the extraction of cocaine and its principle metabolites (norcocaine, benzoylecgonine, ecgonine methyl ester, anhydroecgonine methyl ester and cocaethylene) from whole blood, plasma and urine using polymeric mixed-mode cation exchange SPE columns. EVOLUTE CX mixed-mode resin-based SPE sorbent extracts a wide range of basic analytes from biological fluids and other aqueous matrices using a generic procedure which minimizes method development time. EVOLUTE CX removes matrix components such as proteins, salts, non-ionizable interferences and phospholipids, delivering cleaner extracts with reproducible recoveries for accurate quantitation.