Finding Pathogenic Phenotypes in GWAS Genotypes using RediMODEL

This whitepaper describes how the RediMODEL platform can provide a fast and easy system for robust phenotyping of genotype differences. In the RediMODEL platform, individual human mutations are inserted into the C. elegans genome. This humanization allows the C. elegans model to be used as a powerful system for detecting pathogenic phenotypes in clinically-relevant SNPs associated with human disease.