Flow Electroporation Capabilities and Case Studies: Rapid GPCR Screening and Functional Ion Channel Assays

This technical paper discusses the merits of transient transfection using flow electroporation versus other recombinant expression approaches, and its application in hit identification and lead optimization programs. Data are presented demonstrating the key features of the MaxCyte® STX™ Scalable Transfection System, including broad applicability, scalability, and the production of functionally relevant cells that enable its streamlined integration within cell-based assay methodologies. Case studies are presented for large-scale cellular GPCR screening and the functional characterization of multi-subunit voltage-gated ion channels.