Fluorine Content Analysis in Toothpaste Using NMR

Fluorine is added to toothpaste to help protect against cavities by strengthening the tooth enamel, typical quantities are between 1000 and 1500 ppm and this is strictly regulated as high fluorine levels can lead to health risks. Using Time Domain Nuclear Magnetic Resonance (TD-NMR) the fluorine content can be accurately measured regardless of the particular fluorine compounds and other ingredients present. This application note from Bruker describes this process using its mq Toothpaste Analyzer from the Minispec series.