Future-proofing the Biopharmaceutical QC Laboratory: Using the ACQUITY UPLC H-Class Bio System for HPLC Peptide Mapping

This application note focuses on transitioning HPLC-based biopharmaceutical separations to UPLC-based methods. The procedure for transferring a peptide mapping method from an HPLC quaternary system to the ACQUITY UPLC H-Class Bio System is described. The approach enables the QC laboratory to employ UPLC technology for legacy HPLC methods while transitioning to UPLC methods at a later time.