Future-proofing the Biopharmaceutical QC Laboratory: Using the ACQUITY UPLC H-Class Bio System to Run SEC-HPLC and SEC-UPLC

In this application note, Waters demonstrate that legacy SEC-HPLC methods can be easily transferred to the ACQUITY UPLC H-Class Bio System without any modification to existing method details. With adjustments to flow rate and run time based on changes in particle size and column dimensions, SEC-UPLC can easily be performed with the same ACQUITY UPLC H-Class Bio System without any consequence to protein quantification requirements.