GLUT Family Transporter Involvement in Cellular Uptake of IRDye® 800CW 2-Deoxyglucose

Malignant neoplasms exhibit a higher rate of glucose metabolism when compared to normal cells. In this poster, IRDye® 800CW 2-DG was used as a metabolic marker to paint tumors exhibiting elevated levels of glycolysis. Data presented characterizes the probes action in vitro, providing evidence that IRDye 800CW 2-DG is gaining access to the inner cell environment and that GLUT family transporters are likely playing a key role in that uptake.