High Definition Multiple Reaction Monitoring: The Application of Quadrupole Ion Mobility Time-of-Flight Mass Spectrometry for Targeted Proteomic Studies

Recently the specificity of SRM/MRM peptide quantification has been questioned, prompting the use of high-resolution accurate mass instruments for peptide quantification. This application note demonstrates the benefits of the SYNAPT G2-Si System, in a new High Definition MRM mode, for the quantification of proteins and peptides.