High Definition Multiple Reaction Monitoring: The Application of Quadrupole Ion Mobility Time-of-Flight Mass Spectrometry for Targeted Proteomics Studies

This application note shows the benefits of the SYNAPT G2-Si System for the quantification of proteins and peptides in a new High DefinitionR MRM (HD-MRM) mode, where T-Wave™ ion mobility separations are used with MS/MS mode on a quadrupole time-of-flight mass spectrometer, to provide a highly sensitive and selective quantitative assay with maximum response for all product ions of a molecular peptide ion in a single acquisition.