High throughput Miniaturization of Cytochrome P450 Inhibition Screening Using the Echo® Liquid Handler

4 Nov 2014

This application note demonstrates transfer of enzymes, buffers, microsomes, inhibitors and substrates in small volumes using the Echo 500 series of liquid handlers, providing a sensitive and robust assay. Comparable IC50 values for four known CYP3A4 inhibitors are presented.

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