Highly Sensitive Analysis of Polar Pesticides in Food Matrices on the Xevo TQ-XS

This application note describes a sensitive LC-MS/MS quantification method for the robust analysis of highly polar pesticides in food commodities without the need of derivatization. Using the ACQUITY UPLC System coupled to the Xevo TQ-XS Triple Quadrupole Mass Spectrometer, they achieved sub-parts per billion detection (ppb) limits for glyphosate, glufosinate and aminomethylphosphonic acid (AMPA). The sensitivity of the Xevo TQ-XS promises excellent limits of detection, suitable for monitoring maximum residue limit (MRL) compliance for these challenging analytes and good quantitative performance, in terms of precision and calibration characteristics in compliance with SANTE 11954/2015 guidelines.