Highly sensitive targeted and non-targeted HPLC-MS analysis of PFAS

PFAS are persistent environmental pollutants known for their long lifespan and mobility, leading to accumulation in groundwater and soil with harmful health effects. To mitigate pollution, compounds like PFOA, PFHxS, and long-chain perfluoroalkyl carboxylic acids (C9-C14) are now regulated. This technical note outlines a method for identifying and quantifying PFAS using a YMC-Triart C18 HPLC column, which enhances isomer separation and analytical performance with mass spectrometry.