How to enhance bioprocess control with ZipChip CE-MS for direct mAb quality analysis

As biopharmaceuticals evolve, achieving precise control over monoclonal antibody (mAb) quality is critical for therapeutic efficacy and regulatory compliance. Explore how using ZipChip Capillary Electrophoresis-Mass Spectrometry (CE-MS) for direct spent media analysis enables the efficient monitoring of mAb quality attributes during bioprocessing. By comparing continuous and bolus glucose feeding strategies in CHO cell cultures, learn how ZipChip CE-MS provides insights into molecular weight, charge, and glycoform heterogeneity, with minimal sample preparation. Enhanced product quality, characterized by reduced glycation and improved glycoform profiles, underscores the potential of this method for advancing bioprocess control.