How to Facilitate Filtration of Small Volumes for HPLC and UHPLC Sample Prep

This application note describes methodology that provides guidance for obtaining the smallest hold-up volume possible when filtering small volume samples. The example describes assumes samples will be analyzed by LCMS so we will use a glass syringe and a 13 mm Acrodisc® MS syringe filter designed for low volume samples and low LCMS extractables.