HPLC method to differentiate four THC stereoisomers formed from Δ9-THC degradation

Degradation of Δ⁹-THC to Δ¹⁰-THC and Δ^6a,10a-THC isomers, provides a challenging separation in cannabis-derived products. In this application note, learn how the use of an immobilized cellulose chiral column under normal-phase liquid chromatography conditions provides an analytical method to fully separate these four THC isomers for identification and accurate determination of potency.