Human Liver Microtissues as a Novel System to Predict Inflammation-Mediated Toxicity

The Gravity^Plus system allows the production of regular-sized human liver microtissues with a morphology and architecture close to native liver tissue, in particular when co-cultured with non-parenchymal liver cells. Idiosyncratic toxicity is a severe problem for the pharmaceutical industry. Drugs such as Trovafloxacin were withdrawn due to idiosyncratic hepatotoxicity which was not detected in pre-clinical animal studies. This poster shows, for the first time, an immune-competent in vitro model to study inflammation-mediated toxicity.