Identification and Quantification of Psychedelic Phenethylamine “2C” Series using SPE and LC-MS/MS

The frequent appearance of psychoactive phenethylamine designer drugs has rapidly grown within the past decade and has emerged as a matter of concern for all authorities involved. New phenethylamine drugs are being introduced because these compounds are not covered by existing legislation. Among the most popular in the phenethylamine class are the “2C” compounds, named to denote the two carbon atoms between the phenyl and amine moieties. This application note demonstrates a method for the identification and quantification of these compounds using SPE and LC-MS/MS.